Brian k kobilka biography sample

Robert Lefkowitz and Brian Kobilka were awarded the Nobel Prize in Chemistry for revealing the workings of an important family of receptors: G-protein–coupled receptors (GPCRs).
Every cell in your body is covered with GPCRs, tiny membrane proteins that enable it to sense its environment and allowing it to adapt to new conditions.

Brian k kobilka biography sample

The Kobilka laboratory has been investigating several aspects of GPCR biology. Their primary focus has been adrenergic receptors, which are GPCRs for adrenaline that form the interface between the sympathetic nervous system and the cardiovascular system, and play a critical role in the regulation of cardiovascular function.

Scientists knew that hormones such as adrenalin had powerful effects at a cellular level, and suspected that cell surfaces contained some kind of sensor for hormones, but for years their exact nature remained a mystery.

In Lefkowitz attached a radioactive iodine isotope to various hormones, and used it to